These reference sequences exist independently of genome builds. Explain
These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.
Genomic
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NG_046394.1 RefSeqGene
Range 4980..31554 Download GenBank, FASTA, Sequence Viewer (Graphics)
mRNA and Protein(s)
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NM_001306079.2 → NP_001293008.1 multifunctional protein CAD isoform 2
See identical proteins and their annotated locations for NP_001293008.1
Status: REVIEWED
Description Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5′ coding region compared to variant 1. It encodes isoform 2 which is shorter than isoform 1. Source sequence(s) AC013403, AC013413, AK226105, BC065510, BG766243, BQ447516 Consensus CDS CCDS77396.1 UniProtKB/TrEMBL A0ACI8SLE3, F8VPD4 Related ENSP00000384510.1, ENST00000403525.5 Conserved Domains (4) summary PRK00856Location:1857 → 2161 pyrB; aspartate carbamoyltransferase catalytic subunit PRK12564Location:1 → 355 PRK12564; carbamoyl-phosphate synthase small subunit cd01316Location:1397 → 1743 CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the … TIGR01369Location:391 → 1377 CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit
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NM_001445584.1 → NP_001432513.1 multifunctional protein CAD isoform 3
Status: REVIEWED
Source sequence(s) AC013403, AC013413, KF459621 UniProtKB/TrEMBL A0ACI8PNJ7
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NM_001445585.1 → NP_001432514.1 multifunctional protein CAD isoform 4
Status: REVIEWED
Source sequence(s) AC013403, AC013413, KF459621 UniProtKB/TrEMBL A0ACI8PNJ7
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NM_001445586.1 → NP_001432515.1 multifunctional protein CAD isoform 5
Status: REVIEWED
Source sequence(s) AC013403, AC013413, KF459621 UniProtKB/TrEMBL A0ACI8PNJ7
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NM_001445587.1 → NP_001432516.1 multifunctional protein CAD isoform 6
Status: REVIEWED
Source sequence(s) AC013403, AC013413, KF459621 UniProtKB/TrEMBL A0ACI8SLE3
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NM_001445588.1 → NP_001432517.1 multifunctional protein CAD isoform 7
Status: REVIEWED
Source sequence(s) AC013403, AC013413, KF459621 UniProtKB/TrEMBL A0ACI8SLE3
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NM_001445589.1 → NP_001432518.1 multifunctional protein CAD isoform 8
Status: REVIEWED
Source sequence(s) AC013403, AC013413, KF459621 UniProtKB/TrEMBL A0ACI8SLE3
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NM_001445590.1 → NP_001432519.1 multifunctional protein CAD isoform 9
Status: REVIEWED
Source sequence(s) AC013403, AC013413, KF459621 UniProtKB/TrEMBL A0ACI8SLE3
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NM_001445591.1 → NP_001432520.1 multifunctional protein CAD isoform 10
Status: REVIEWED
Source sequence(s) AC013403, AC013413, KF459621 UniProtKB/TrEMBL A0ACI8SLE3
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NM_001445592.1 → NP_001432521.1 multifunctional protein CAD isoform 11
Status: REVIEWED
Source sequence(s) AC013403, AC013413, KF459621 UniProtKB/TrEMBL A0ACI8PNJ7
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NM_001445593.1 → NP_001432522.1 multifunctional protein CAD isoform 12
Status: REVIEWED
Source sequence(s) AC013403, AC013413, KF459621 UniProtKB/TrEMBL A0ACI8SLE3
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NM_004341.5 → NP_004332.2 multifunctional protein CAD isoform 1
See identical proteins and their annotated locations for NP_004332.2
Status: REVIEWED
Description Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Source sequence(s) AC013403, AC013413, BC065510, BM927624, BQ447516, BU541191, BU558264, D78586 Consensus CDS CCDS1742.1 UniProtKB/Swiss-Prot D6W552, P27708, Q6P0Q0, Q96CK3 UniProtKB/TrEMBL A0ACI8SLE3 Related ENSP00000264705.3, ENST00000264705.9 Conserved Domains (13) summary cd01744Location:178 → 354 GATase1_CPSase; Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II PRK09060Location:1429 → 1810 PRK09060; dihydroorotase; Validated PRK00856Location:1920 → 2224 pyrB; aspartate carbamoyltransferase catalytic subunit; Provisional PRK12564Location:1 → 355 PRK12564; carbamoyl phosphate synthase small subunit; Reviewed cd01316Location:1460 → 1806 CAD_DHOase; The eukaryotic CAD protein is a trifunctional enzyme of carbamoylphosphate synthetase-aspartate transcarbamoylase-dihydroorotase, which catalyzes the first three steps of de novo pyrimidine nucleotide biosynthesis. Dihydroorotase (DHOase) catalyzes the … cd01423Location:1313 → 1438 MGS_CPS_I_III; Methylglyoxal synthase-like domain found in pyr1 and URA1-like carbamoyl phosphate synthetases (CPS), including ammonia-dependent CPS Type I, and glutamine-dependent CPS Type III. These are multidomain proteins, in which MGS is the C-terminal domain. TIGR01369Location:391 → 1440 CPSaseII_lrg; carbamoyl-phosphate synthase, large subunit pfam00185Location:2072 → 2221 OTCace; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain pfam00988Location:2 → 138 CPSase_sm_chain; Carbamoyl-phosphate synthase small chain, CPSase domain pfam02729Location:1925 → 2065 OTCace_N; Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain pfam02786Location:514 → 716 CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain pfam02787Location:801 → 921 CPSase_L_D3; Carbamoyl-phosphate synthetase large chain, oligomerization domain cl17255Location:1048 → 1245 ATP-grasp_4; ATP-grasp domain